Matt Cain Throws the 22nd Perfect Game in MLB History!

Matt Cain powered through the Houston Astros on Wednesday night, striking out a career-high 14 and tossing the first perfect game in San Francisco Giants history.

Cain's dominant outing in a 10-0 win over the Astros was the second perfect game in the major leagues this season and the 22nd of all time.

Chicago White Sox pitcher Philip Humber tossed this year's first perfecto on April 21 against the Seattle Mariners.During an on-field interview with the studio crew of "MLB Tonight" on MLB Network, Cain was still coming to grips with the weight of his accomplishment.

"Honestly, I have no idea what it means. This is unspeakable right now. This is unbelievable," Cain marveled. "This is something that, obviously, [is] part of history, something that I'm going to remember forever. This is truly amazing right now."

The Giants put crooked numbers on the board in four of the first five frames to jump out to a large lead. By the later innings, the only drama remaining involved Cain's bid for a perfecto.

The closest call for Cain was saved by a stellar catch in right field by Gregor Blanco in the seventh inning to rob Schafer of what looked to a sure hit to the gap. An inning earlier, Giants left fielder Melky Cabrera also made a terrific snag to keep the Astros off the base paths.